How Mitochondrial Dynamism Orchestrates Mitophagy
نویسندگان
چکیده
منابع مشابه
How mitochondrial dynamism orchestrates mitophagy.
Mitochondria are highly dynamic, except in adult cardiomyocytes. Yet, the fission and fusion-promoting proteins that mediate mitochondrial dynamism are highly expressed in, and essential to the normal functioning of, hearts. Here, we review accumulating evidence supporting important roles for mitochondrial fission and fusion in cardiac mitochondrial quality control, focusing on the PTEN-induced...
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www.landesbioscience.com Cell Cycle 3131 Due to the key role of mitochondria in cell metabolism, the quantity and quality of this organelle must be maintained properly, which is achieved by constitutive mitochondrial fusion and fission as well as biogenesis and degradation. A fission complex controls mitochondrial division, whereas degradation occurs primarily through autophagy. The latter can ...
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MicroRNAs (miRNAs) are short, 22–25 nucleotide long transcripts that may suppress entire signaling pathways by interacting with the 3’-untranslated region (3’-UTR) of coding mRNA targets, interrupting translation and inducing degradation of these targets. The long 3’-UTRs of brain transcripts compared to other tissues predict important roles for brain miRNAs. Supporting this notion, we found th...
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ژورنال
عنوان ژورنال: Circulation Research
سال: 2015
ISSN: 0009-7330,1524-4571
DOI: 10.1161/circresaha.116.306374